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河南大学人才特区特聘教授——李伟
2019-05-16 08:39   审核人:   (阅读:)

教育经历

1987年,河南医科大学医学系医学学士

1990年,河南医科大学生理系医学硕士

1999年,加拿大曼尼托巴大学生理系哲学博士

工作经历

1990-1992  河南医科大学生理系助教

1992-1993 中国科学院上海脑研究所进修

2000-2002 美国宾西法尼亚大学博士后

2002-2005 美国爱因斯坦医学院博士后,讲师

2005-2018 美国范因司坦医学研究所助理研究员,助理教授

2016-至今 河南大学黄河学者,特聘教授,淮河医院脓毒症实验室主任。

发明专利

1)甘珀酸及其盐在制备治疗炎症性疾病的药物中的应用(中国发明专利号:ZL201310173466.7)。

2)SAA Domain-specific Antibodies And Peptide Antagonists And Use Thereof To Treat Inflammatory Diseases (美国专利号:9458232B2)

3)Hemichannel Extracellular-domain Specific Agents For Treating Sepsis (美国专利申请2016)

4)Use Of Tetranectin And Peptide Agonists To Treat Inflammatory Diseases (美国专利预申请号:62/514,085, 2017)

5)Connexin模拟肽在制备预防或治疗急性肺损伤药物中的应用(中国发明专利申请号:201710902407.7)。

6)四连接素模拟肽TNP及其应用(中国发明专利申请号:2018072400911440)。

科研项目

1) HMGB1在毒血症中释放的调节, 美国国立卫生研究院, R01 GM063075, 2007-2021。

2) 新的中药治疗脓毒血症方法的机制, 美国国立卫生研究院, R01 AT005076, 2010-2019。

3)新型connexin43半通道阻断剂的建立及脓毒症发病机制研究,中国国家自然科学基金委员会,面上项目81671959, 2017-2020。

4)Connexin半通道在急性肺损伤的作用及其调节HMGB1释放的机制,NSFC-河南省联合基金 U1704171, 2018-2020。

科研论文

1*Li, W., Li, H.X. and Cao, X.C. (1992) Effects of stimulation and lesion of LC on the discharges of NGC neurons. Basic Medical Sciences and Clinics, 12, 239-243.

 

2. *Kong, T.H., Fan, T.S., Han, X.F., Li, W. and Lei, L.G. (1992) Research on serotonergic neurons in lateral raphe nucleus of rat with intracellular injection HRP technique. Acupuncture Res., 17, 196-200.

3. Li, W. and Z.Q. Zhao (1993) Yohimbine reduces inhibition of lamina X neurones by stimulation of the locus coeruleus. Neuroreport, 4, 751-753.

 

4. Li, W., Ochalski, P.A.Y., Brimijoin, S., Jordan, L.M. and Nagy, J.I. (1995) C-terminals on motoneurons: electron microscope localization of cholinergic markers in adult rats and antibody-induced depletion in neonates. Neuroscience, 65, 879-891.

 

5. Nagy, J.I., Li, W., Hertzberg, E.L. and Marotta, C.A. (1996) Elevated connexin43 immunoreactivity at sites of amyloid plaques in Alzheimer's disease. Brain Res., 717, 173-178.

 

6. Nagy, J.I., Li, W., Roy, C., Doble, B.W., Gilchrist, J.S., Kardami, E. and Hertzberg, E.L. (1997) Selective monoclonal antibody recognition and cellular localization of an unphosphorylated form of connexin43. Exp. Cell Res., 236, 127-136.

 

7. Li, W., Ochalski, P.A.Y., Hertzberg, E.L. and Nagy, J.I. (1998) Immunorecognition, ultrastructure and phosphorylation status of astrocytic gap junctions and connexin43 in rat brain after cerebral focal ischemia. Eur. J. Neurosci., 10, 2444-2463.

 

8. Li, W. and Nagy, J.I. (2000) Activation of fibres in rat sciatic nerve alters phosphorylation state of connexin-43 at astrocytic gap junctions in spinal cord: evidence for junction regulation by neuronal-glial interactions. Neuroscience, 97, 113-123.

 

9. Li, W. and Nagy, J.I. (2000) Connexin43 phosphorylation state and intercellular communication in cultured astrocytes following hypoxia and protein phosphatase inhibition. Eur. J. Neurosci., 12, 2644-2650.

 

10. Nagy, J.I. and Li, W. (2000) A brain slice model for in vitro analyses of astrocytic gap junction and connexin43 regulation: actions of ischemia, glutamate and elevated potassium. Eur. J. Neurosci., 12, 4567-4572.

 

11. Xu, X., Li, W., Huang, G.Y., Meyer, R., Chen, T., Luo, Y. Thomas, M.P., Radice G.L.R..and Lo, C.W. (2001) Modulation of mouse neural crest cell motility by N-cadherin and connexin 43 gap junctions. J. Cell Biol., 154, 217-229.

 

12. Li, W., Waldo, K., Linask, K.K., Wessels, A., Parmacek, M., Kirby, M.L. and Lo, C.W. (2002) An essential role for connexin 43 gap junctions in mouse coronary artery development. Development, 129, 2031-2042.

 

13. Xu, X., Li, W., Huang, G.Y., Meyer, R., Chen, T., Luo, Y., Thomas, M.P., Radice, G.L. and Lo, C.W. (2002) N-cadherin and Cx43a1 gap junctions modulates mouseneural crest cell motility via distinct pathways. Cell Adhesion Comm., 8, 321-324.

14. Iacobas, D.A., Iacobas, S., Li, W., Zoidl, G., Dermietzel, R., & Spray, D.C. (2005) Genes controlling multiple functional pathways are transcriptionally regulated in connexin43 null mouse heart. Physiol Genomics 20, 211-223.

 

15.  Li, W., Hertzberg, E.L., & Spray, D.C. (2005) Regulation of connexin43-protein binding in astrocytes in response to chemical ischemia/hypoxia. J Biol. Chem 280, 7941-7948.

 

16.  Nicchia, G.P., Srinivas, M., Li, W., Brosnan, C.F., Frigeri, A., & Spray, D.C. (2005) New possible roles for aquaporin-4 in astrocytes: cell cytoskeleton and functional relationship with connexin43. FASEB J 19, 1674-1676.

17. Chen, X., Li, W., & Wang, H. (2006) More tea more septic patients? – Green tea suppresses endotoxin-induced release of high mobility group box 1 (HMGB1). Medical Hypotheses 66(3): 660-663.

 

18. Wang, H., Li, W., Li, J., Rendon-Mitchell, B., Ochani, M., Yang, L., Ashok, M., Yang, H., Tracey, K.J., Wang, P. & Sama A.E. (2006) A popular Chinese herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis. J. Nutrition 136: 136(2): 360-365.

 

19. Li, W., Sama, A.E. & Wang, H. (2006) Role of HMGB1 in cardiovascular disease. Current Opinion in Pharmacology 6(2): 130-135.

 

20. Wang, H., M.F. Ward, X.G. Fan, A.E. Sama, & W. Li. (2006) Potential role of HMGB1 in viral infectious diseases. Viral Immunology 19(1): 3-9.

 

21. Li, W., Li, J. Ward, M.F., Sama, A.E. & Wang, H. (2006) Discovery of HMGB1 as a self-destructive nuclear weapon in lethal sepsis. In: Recent Research Development in Experimental Medicine, 2nd Issue. Transworld Research Network, Kerala, India (Book Chapter, in press).

22. Wang, H., W. Li, R. Goldstein, K.J. Tracey, & A.E. Sama. (2007). HMGB1 as a potential therapeutic target. In: Novartis Foundation Symposium 280: Sepsis – New Insights, New Therapies. pp73-91, New York: John Wiley & Sons.

 

23. Li, W., J., Li, M. Ashok, R. Wu, D. Chen, L. Yang, H. Yang, K.J. Tracey, P. Wang, A.E. Sama, and H. Wang. (2007). A cardiovascular drug rescues mice from lethal sepsis by attenuating late-acting proinflammatory mediator, HMGB1. J. Immunology 178(6): 3856-3864.

 

24. Li, W., M. Ashok, J., Li, H. Yang, A.E. Sama, and H. Wang. (2007). A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1. PLoS ONE 2(11): e1153 (1-11).

25. Wang, H., S. Zhu, R. Zhou, W. Li, and A.E. Sama. (2008). Therapeutic potential of HMGB1-targeting agents in sepsis. Expert Rev. Mol. Med. 10: e32.

 

26. Zhu, S., W. Li, J. Li, A.E. Sama, and H. Wang. (2008) Caging a Beast in the Inflammation Arena: Use of Chinese Medicinal Herbs to Inhibit a Late Mediator of Lethal Sepsis, HMGB1. Int. J. Clin. Exp. Med. 1(1): 64-75.

27. Zhu, S., M. Ashok, J. Li, W. Li, H. Yang, P. Wang, K.J. Tracey, A.E. Sama, and H. Wang (2009) Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers. Mol. Med. 15 (7-8) 275-282.

 

28. Zhu, S., W. Li, M.F. Ward, A.E. Sama, and H. Wang (2010) High mobility group box 1 protein as a potential drug target for infection- and injury-elicited inflammation. Inflamm. Allergy Drug Targets 9(1) :60-72.

 

29. Wang, H., W. Li, S. Zhu, J. Li, J. D’Amore, M.F. Ward, H. Yang, R. Wu, W. Jahnen-Dechent, K.J. Tracey, P. Wang, and A.E. Sama (2010) Peripheral administration of fetuin-A attenuates early cerebral ischemic injury in rats. J Cereb Blood Flow Metab. 30(3):493-504.

30. Li W, Zhu S, Li J, Huang Y, Zhou R, Fan X, Yang H, Gong X, Eissa NT, Jahnen-Dechent W, Wang P, Tracey KJ, Sama AE, Wang H. (2011) A hepatic protein, fetuin-A, occupies a protective role in lethal systemic inflammation. PLoS One. 6(2):e16945.

 

31. Li W, Zhu S, Li J, Assa A, Jundoria A, Xu J, Fan S, Eissa NT, Tracey KJ, Sama AE, Wang H. (2011) EGCG stimulates autophagy and reduces cytoplasmic HMGB1 levels in endotoxin-stimulated macrophages. Biochem Pharmacol. 81(9):1152-63.

 

32. Li W, Zhu S, Zhang Y, Li J, Sama AE, Wang P, Wang H. (2012) Use of animal model of sepsis to evaluate novel herbal therapies. J Vis Exp. 11;(62).

 

33. Zhu S, Li W, Li J, Jundoria A, Sama AE, Wang H. (2012) It Is Not Just Folklore: The Aqueous Extract of Mung Bean Coat Is Protective against Sepsis. Evid Based Complement Alternat Med. 2012:498467.

 

34. Zhang Y, Li W*, Zhu S, Jundoria A, Li J, Yang H, Fan S, Wang P, Tracey KJ, Sama AE, Wang H. (2012) Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake. Biochem Pharmacol. 84(11):1492-500.

 

35. Li W, Li J, Sama AE, Wang H. (2013) Carbenoxolone Blocks Endotoxin-Induced Protein Kinase R (PKR) Activation and High Mobility Group Box 1 (HMGB1) Release. Mol Med. 19(1):203-11.

 

36. Zhao, L, Li W, Zhu S, Tsai S, Li J, Tracey KJ, Wang W, Fan S, Sama AE, and Wang H. 2013. Green tea catechins quench the fluorescence of bacteria-conjugated Alexa Fluor Dyes. Inflamm. Allergy Drug Targets. 12(5): 308-314.

 

37. Lu B Wang C Wang M Li W, Chen F, Tracey KJ, and Wang H (2014) Expert Rev. Clin Immunol, 10(6) 713-27.

38. Li W, Zhu S, Li J, Long W, D’Amore J, D’Angelo J, Yang H, Wang P, Tracey K, and Haichao Wang (2015) Serum amyloid A stimulates PKR expression and HMGB1 release possibly through TLR4/RAGE receptors. Mol Med, 32, 515-25.

39. Li W, Wu AH, Zhu S, Li J, Wu R, D’Angelo J, and Wang H (2015) EGCG induces G-CSF expression and neutrophilia in experimental sepsis. Immunol. Res. 63, 144-52.

40. Yang H, Wang H, Levine YA, Gunasekaran MK, Wang Y, Addorisio M, Zhu S, Li W, Li J, de Kleijn DP, Olofsson PS, Warren HS, He M, Al-Abed Y, Roth J, Antoine DJ, Chavan SS, Andersson U, Tracey KJ (2016) Identification of CD163 as an anti-inflammatory receptor for HMGB1-haptoglobin complexes. JCI Insight 1(7) e85375.

41. Zhu S, Wang Y, Chen W, Li W, Wang A, Wong S, Bao G, Li J, Yang H, Tracey KJ, D'Angelo J, Wang H (2016) High-Density Lipoprotein (HDL) Counter-Regulates Serum Amyloid A (SAA)-Induced sPLA2-IIE and sPLA2-V Expression in Macrophages PLoS One 11(11):e0167468.

42. Zhao L, Liu S, Xu J, Li W, Duan G, Wang H, Yang H, Yang Z, Zhou R.(2017) A new molecular mechanism underlying the EGCG-mediated autophagic modulation of AFP in HepG2 cells. Cell Death Dis. 8(11):e3160.

43. Li W, Bao G, Chen W, Qiang X, Zhu S, Wang S, He M, Ma G, Ochani M, Al-Abed Y, Yang H, Tracey KJ, Wang P, D'Angelo J, Wang H. (2018) Connexin 43 Hemichannel as a Novel Mediator of Sterile and Infectious Inflammatory Diseases. Sci Rep. 8(1):166.

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