1.个人信息
王向东，男，医学博士，特聘教授，博士导师，Xdwang@fuccb.com
学术任职：河南大学特聘教授，河南省人民医院临床单细胞生物医学中心主任，中国生物医药协会基因检测分会主任委员、中国医师协会精准医疗专业委员会副主任委员兼总干事。伦敦大学国王学院兼职教授。国际转化医学协会执行主席，中国抗癌协会肿瘤精准治疗专业委员会常委，世界华人医师协会副会长兼理事，世界华人肿瘤医师协会常务副主任委员兼总干事。还担任细胞生物学与毒理学杂志（IF=3.39）的主编，临床转化医学杂志执行主编、转化生物信息学系列从书主编，转化医学杂志疾病生物标志物主编（IF=4.17），细胞分子医学杂志亚洲主编（IF= 4.38）；和国际专业编委，如美国呼吸重症医学杂志（IF=15），美国的细胞和分子生物学杂志（IF= 5）。
2.受教育经历
起止时间 地点、机构 专业 学位
1977-1982 哈尔滨医科大学 医学 学士
1985-1987 哈尔滨医科大学附属第一医院 肝胆外科 硕士
1987-1989 北京医科大学附属三院 外科 博士
1990-1993 瑞典隆德大学 医学 博士
1994-1995 美国贝尔医学院 细胞分子生物学 博士
3.工作经历
1982-1985 哈尔滨市第一医院 助教 医师
1993-1997 瑞典隆德大学 实验室主任 教授
2000- 2006 阿斯利康（ASTRAZENECA）制药公司 主任科学家 教授
2008至今 复旦大学中山医院 特聘教授 教授
2015至今 上海市临床生物信息学研究所 所长 教授
2016至今 复旦大学中山医院临床医学研究院 执行院长 教授
2016至今 河南省人民医院临床单细胞生物医学中心 主任 教授
4.研究兴趣
主要研究临床生物信息学，疾病特异性生物标志物，慢性肺疾病，肿瘤免疫学，分子和细胞疗法。正在开展精准医疗应用，融组学、生物信息学、临床信息学为一体对疾病特异性标志物识别和验证，临床跨组学，研发慢性肺疾病和肺癌的治疗靶标。开发蝶型化学结构的磷酸肌醇3-激酶抑制剂预防和治疗慢性肺部炎症和损伤。
5.承担项目情况（一般为近5年内的）
承担科研项目（第一承担人）
国家“十三五”精准医疗重大专项，2017年度项目，项目名称:基于临床生物信息学研发慢性阻塞性肺病的个体化治疗靶标和新技术，1950万，2018.01.01-2020.12.31
国家自然科学基金，2013年度项目，项目名称:PI3K信号通路介导过程对肺损伤的保护作用及机制。PI:方晓聪，指导人
国家自然科学基金2013年度国际合作重点专项，项目批准号：81320108001，项目名称: 特络细胞靶向调节网络在肺损伤和修复中的作用及其分子机制编号，280万人民币，2014.01.01-2018.12.31。
国家自然科学基金2012年度重点专项，项目批准号：91230204，项目名称:基于小样本数据的高维生物系统重构理论及算法与应用，300万人民币，2013.01.01-2016.12.31。
国家自然科学基金2012年度项目，编号：81270099，项目名称:骨桥蛋白在慢性阻塞性肺病急性发作期对PI3K-δ及IL-17F调控机理研究，80万人民币，2013.01.01-2015.12.31。
上海市科委2012年度“创新行动计划”基础研究重点项目，编号12JC1402200，题目：PI3K相关小分子代谢产物对肺癌淋巴细胞的作用及其在肺癌发生发展机制研究，60万人民币，2013.01.01-2015.12.31 。
上海市科委2012年度“科技创新行动计划”生物医药领域成果转化与应用专项，编号12431900207，题目：抗肿瘤新药-蝶状PI3K抑制剂SHBM-1009的成药性研究，30万人民币，2012.09.30-2015.09.30 。
上海市科委2012年度国际合作项目，编号：11410708600，题目：慢性阻塞性肺病动态生物标记物网络研究，30万人民币，2011.09.30-2014.09.30。
美国BD公司合作项目，题目：创建中国分子免疫中心(COE)，平台建设3000万人民币，科研经费180万人民币，2012.03.01-2015.02.28。
美国BD公司合作项目，题目：细胞移植治疗标准化研究平台，30万人民币，2012.03.01-2014.02.28
温州医学院一院合作项目，题目：建立温州医学院一院临床转化医学研究院，平台建设1000万人民币，科研经费100万人民币，2011.0101-2015.01.01。
6.代表性论著
论文、奖励、专利等（一般为近5年内的）
原创论文发表
2018
Wang X. Why 3D genome alternations play important roles in diseases. Semin Cell Dev Biol. 2018 Aug 7. pii: S1084-9521(18)30181-2. doi: 10.1016/j.semcdb.2018.07.024. (IF=6.138)
Wang DC, Wang W, Zhang L, Wang X. A tour of 3D genome with a focus on CTCF. Semin Cell Dev Biol. 2018 Jul 23. pii: S1084-9521(18)30160-5. doi: 10.1016/j.semcdb.2018.07.020. (IF=6.138)
Qian M, Cheng Y, Wang X. The methodology study of three-dimensional (3D) genome research. Semin Cell Dev Biol. 2018 Jul 19. pii: S1084-9521(17)30594-3. doi: 10.1016/j.semcdb.2018.07.003. (IF=6.138)
Fu S, Zhang L, Lv J, Zhu B, Wang W, Wang X. Two Main Stream Methods Analysis and Visual 3D Genome Architecture. Semin Cell Dev Biol. 2018 Aug 16. pii: S1084-9521(17)30589-X. doi: 10.1016/j.semcdb.2018.07.011. (IF=6.138)
Wang W, Zhang L, Wang X, Zeng Y. The advances in CRISPR technology and 3D genome. Semin Cell Dev Biol. 2018 Aug 25. pii: S1084-9521(17)30610-9. doi: 10.1016/j.semcdb.2018.07.009. (IF=6.138)
Hou J, Wang X. The Polycomb group proteins functions in epithelial to mesenchymal transition in lung cancer. Semin Cell Dev Biol. 2018 Jul 21. pii: S1084-9521(17)30595-5. doi: 10.1016/j.semcdb.2018.07.010. (IF=6.138)
Zhang L, Song D, Zhu B, Wang X. The role of nuclear matrix protein HNRNPU in maintaining the architecture of 3D genome. Semin Cell Dev Biol. 2018 Jul 20. pii: S1084-9521(18)30050-8. doi: 10.1016/j.semcdb.2018.07.006. (IF=6.138)
Liu F, Wu D, Wang X. Roles of CTCF in conformation and functions of chromosome. Semin Cell Dev Biol. 2018 Jul 28. pii: S1084-9521(18)30005-3. doi: 10.1016/j.semcdb.2018.07.021. (IF=6.138)
Yan F, Wang X, Zeng Y. 3D genomic regulation of lcnRNA and Xist in X chromosome. Semin Cell Dev Biol. 2018 Jul 14. pii: S1084-9521(18)30159-9. doi: 10.1016/j.semcdb.2018.07.013. (IF=6.138)
Gao D, Zhu B, Cao X, Zhang M, Wang X. Roles of NIPBL in maintenance of genome stability. Semin Cell Dev Biol. 2018 Aug 17. pii: S1084-9521(18)30162-9. doi: 10.1016/j.semcdb.2018.08.005. (IF=6.138)
Zhu Z, Wang X. Roles of cohesin in chromosome architecture and gene expression. Semin Cell Dev Biol. 2018 Aug 17. pii: S1084-9521(18)30165-4. doi: 10.1016/j.semcdb.2018.08.004. (IF=6.138)
Liu X, Li S, Jin J, Zhu T, Xu K, Liu C, Zeng Y, Mao R, Wang X, Chen Z. Preventative tracheal administration of interleukin-27 attenuates allergic asthma by improving the lung Th1 microenvironment. J Cell Physiol. 2018 Oct 26. doi: 10.1002/jcp.27422. (IF=3.923)
Wang DC, Wang X. Genome dimensions control biological and toxicological functions; myth or reality? Cell Biol Toxicol. 2018 Jul 14; 34(5): 333–336. doi: 10.1007/s10565-018-9440-2. (IF=3.39)
Lv J, Gao D, Zhang Y, Wu D, Shen L, Wang X. Heterogeneity of lipidomic profiles among lung cancer subtypes of patients. J Cell Mol Med. 2018 Oct;22(10):5155-5159. doi: 10.1111/jcmm.13782. (IF=4.3)
Shi L, Shi L, Wang X, He J. Regulatory Roles of Osteopontin in Production of Monocyte-Origin MCP-1. Cell Transplant. 2018 Aug;27(8):1185-1194. doi: 10.1177/0963689718756070. (IF=2.885)
Wang DC, Wang W, Zhu B, Wang X. Lung Cancer Heterogeneity and New Strategies for Drug Therapy. Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:531-546. doi: 10.1146/annurev-pharmtox-010716-104523. (IF=13)
Shi L, Dong N, Ji D, Huang X, Ying Z, Wang X, Chen C. Lipopolysaccharide-induced CCN1 production enhances interleukin-6 secretion in bronchial epithelial cells. Cell Biol Toxicol. 2018 Feb;34(1):39-49. doi: 10.1007/s10565-017-9401-1. (IF=3.39)
Shi L, Zhu B, Xu M, Wang X. Selection of AECOPD-specific immunomodulatory biomarkers by integrating genomics and proteomics with clinical informatics. Cell Biol Toxicol. 2018 Apr;34(2):109-123. doi: 10.1007/s10565-017-9405-x. (IF=3.39)
Wang W, Gao D, Wang X. Can single-cell RNA sequencing crack the mystery of cells? Cell Biol Toxicol. 2018 Apr;34(2):109-123. doi: 10.1007/s10565-017-9405-x. (IF=3.39)
Zeng Y, Chen X, Gao H, Wang X. An artificial intelligent single cell is part of the cell dream world. Cell Biol Toxicol. 2018 Aug;34(4):247-249. doi: 10.1007/s10565-018-9433-1. (IF=3.39)
Wu D, Wang X, Sun H. The role of mitochondria in cellular toxicity as a potential drug target. Cell Biol Toxicol. 2018 Apr;34(2):87-91. doi: 10.1007/s10565-018-9425-1. (IF=3.39)
Wang X. Clinical trans-omics: an integration of clinical phenomes with molecular multiomics. Cell Biol Toxicol. 2018 Jun;34(3):163-166. doi: 10.1007/s10565-018-9431-3. (IF=3.39)
Zeng Y, Chen X, Wang X. Roles of Single Cell Systems Biomedicine in Lung Diseases. Adv Exp Med Biol. 2018;1068:177-185. doi: 10.1007/978-981-13-0502-3_15. (IF=1.76)
Zhuge W, Yan F, Zhu Z, Wang X. The Significance of Single-Cell Biomedicine in Stem Cells. Adv Exp Med Biol. 2018;1068:187-195. doi: 10.1007/978-981-13-0502-3_16. (IF=1.76)
Qian M, Spada C, Wang X. Detection and Application of RNA Editing in Cancer. Adv Exp Med Biol. 2018;1068:159-170. doi: 10.1007/978-981-13-0502-3_13. (IF=1.76)
Wang Y, Li L, Wang X, Gu J. Can the Single Cell Make Biomedicine Different? Adv Exp Med Biol. 2018;1068:1-6. doi: 10.1007/978-981-13-0502-3_1. (IF=1.76)
2017
Dong N, Shi L, Wang DC, Chen C, Wang X. Role of epigenetics in lung cancer heterogeneity and clinical implication. Semin Cell Dev Biol. 2017 Apr;64:18-25. (IF=6.614)
Gao D, Zhu B, Sun H, Wang X. Mitochondrial DNA Methylation and Related Disease. Adv Exp Med Biol. 2017;1038:117-132. doi: 10.1007/978-981-10-6674-0_9. (IF=1.8)
Gu J, Wang X. Piercing the "armor" of lung cancer with genome medicine. Semin Cancer Biol. 2017 Feb;42:1-3. (IF=9.141)
He M, Hou J, Wang L, Zheng M, Fang T, Wang X, Xia J. Actinidia chinensis Planch root extract inhibits cholesterol metabolism in hepatocellular carcinoma through upregulation of PCSK9. Oncotarget. 2017 Jun 27;8(26):42136-42148.
Hou J, Eldeeb M, Wang X. Beyond Deubiquitylation: USP30-Mediated Regulation of Mitochondrial Homeostasis. Adv Exp Med Biol. 2017;1038:133-148. doi: 10.1007/978-981-10-6674-0_10.
Huang A, Zhao X, Yang XR, Li FQ, Zhou XL, Wu K, Zhang X, Sun QM, Cao Y, Zhu HM, Wang XD, Yang HM, Wang J, Tang ZY, Hou Y, Fan J, Zhou J. Circumventing intratumoral heterogeneity to identify potential therapeutic targets in hepatocellular carcinoma. J Hepatol. 2017 Aug;67(2):293-301.
Liu F, Sanin DE, Wang X. Mitochondrial DNA in Lung Cancer. Adv Exp Med Biol. 2017;1038:9-22. doi: 10.1007/978-981-10-6674-0_2.
Liu X, Hou J, Wang X, Chen Z. An intimal sarcoma of pulmonary artery mimicking pulmonary embolism: a case report and literature review. Respirol Case Rep. 2017 Jun 28;5(5):e00248.
Lu J, Wang W, Xu M, Li Y, Chen C, Wang X. A global view of regulatory networks in lung cancer: An approach to understand homogeneity and heterogeneity. Semin Cancer Biol. 2017 Feb;42:31-38. (IF=9.141)
Lv J, Bhatia M, Wang X. Roles of Mitochondrial DNA in Energy Metabolism. Adv Exp Med Biol. 2017;1038:71-83. doi: 10.1007/978-981-10-6674-0_6.
Qian M, Fang X, Wang X. Autophagy and inflammation. Clin Transl Med. 2017 Dec;6(1):24.
Qian M, Spada C, Wang X. Approach, Application, and Bioethics of mtDNA Sequencing in Cancer. Adv Exp Med Biol. 2017;1038:23-38. doi: 10.1007/978-981-10-6674-0_3.
Qian M, Zhu B, Wang X, Liebman M. Drug resistance in ALK-positive Non-small cell lungcancer patients. Semin Cell Dev Biol. 2017 Apr;64:150-157. (IF=6.614)
Sanden C, Mori M, Jogdand P, Jönsson J, Krishnan R, Wang X, Erjefält JS. Broad Th2 neutralization and anti-inflammatory action of pentosan polysulfate sodium in experimental allergic rhinitis. Immun Inflamm Dis. 2017 Sep;5(3):300-309. doi: 10.1002/iid3.164.
Shi L, Wang X. Role of osteopontin in lung cancer evolution and heterogeneity. Semin Cell Dev Biol. 2017 Apr;64:40-47. (IF=6.614)
Shi L, Zheng M, Hou J, Zhu B, Wang X. Regulatory roles of epigenetic modulators, modifiers and mediators in lung cancer. Semin Cancer Biol. 2017 Feb;42:4-12. (IF=9.141)
Song D, Cretoiu D, Wang X. Mitochondrial DNA in Telocytes. Adv Exp Med Biol. 2017;1038:55-70. doi: 10.1007/978-981-10-6674-0_5.
Sun H, Shi W, Wang X. How Far Can Mitochondrial DNA Drive the Disease? Adv Exp Med Biol. 2017;1038:1-8. doi: 10.1007/978-981-10-6674-0_1.
Wang DC, Wang X. Systems heterogeneity: An integrative way to understand cancer heterogeneity. Semin Cell Dev Biol. 2017 Apr;64:1-4. (IF=6.614)
Wang DC, Wang X. Tomorrow's genome medicine in lung cancer. Semin Cancer Biol. 2017 Feb;42:39-43. (IF=9.141)
Wang L, Liebmen MN, Wang X. Roles of Mitochondrial DNA Signaling in Immune Responses. Adv Exp Med Biol. 2017;1038:39-53. doi: 10.1007/978-981-10-6674-0_4.
Wang L, Zhu B, Zhang M, Wang X. Roles of immune microenvironment heterogeneity in therapy-associated biomarkers in lung cancer. Semin Cell Dev Biol. 2017 Apr;64:90-97. (IF=6.614)
Wang W, Hou J, Zhu Z, Fang H. Is Mitochondrial Cell Fragility a Cell Weakness? Adv Exp Med Biol. 2017;1038:107-116. doi: 10.1007/978-981-10-6674-0_8.
Wang W, Wang X. Single-cell CRISPR screening in drug resistance. Cell Biol Toxicol. 2017 Jun;33(3):207-210.
Wang W, Zhu B, Wang X. Dynamic phenotypes: illustrating a single-cell odyssey. Cell Biol Toxicol. 2017 Oct;33(5):423-427. doi: 10.1007/s10565-017-9400-2.
Wu D, Wang DC, Cheng Y, Qian M, Zhang M, Shen Q, Wang X. Roles of tumor heterogeneity in the development of drug resistance: A call for precision therapy. Semin Cancer Biol. 2017 Feb;42:20-30. (IF=9.141)
Wu D, Zhuo L, Wang X. Metabolic reprogramming of carcinoma-associated fibroblasts and its impact on metabolic heterogeneity of tumors. Semin Cell Dev Biol. 2017 Apr;64:125-131. (IF=6.614)
Xu M, Wang DC, Wang X, Zhang Y. Correlation between mucin biology and tumor heterogeneity in lung cancer. Semin Cell Dev Biol. Semin Cell Dev Biol. 2017 Apr;64:73-78. (IF=6.614)
Ye L, Song D, Jin M, Wang X. Therapeutic roles of telocytes in OVA-induced acute asthma in mice. J Cell Mol Med. 2017 Nov;21(11):2863-2871. doi: 10.1111/jcmm.13199.
Zhang L, Reyes A, Wang X. The Role of DNA Repair in Maintaining Mitochondrial DNA Stability. Adv Exp Med Biol. 2017;1038:85-105. doi: 10.1007/978-981-10-6674-0_7.
Zhang L, Wang W, Zhu B, Wang X. Epithelial Mitochondrial Dysfunction in Lung Disease. Adv Exp Med Biol. 2017;1038:201-217. doi: 10.1007/978-981-10-6674-0_14.
Zhang L, Wang W, Zhu B, Wang X. Regulatory Roles of Mitochondrial Ribosome in Lung Diseases and Single Cell Biology. Adv Exp Med Biol. 2017;1038:183-200. doi: 10.1007/978-981-10-6674-0_13.
Zhu HX, Shi L, Zhang Y, Zhu YC, Bai CX, Wang XD, Zhou JB. Myocyte enhancer factor 2D provides a cross-talk between chronic inflammation and lung cancer. J Transl Med. 2017 Mar 24;15(1):65.
Zhu Z, Wang X. Significance of Mitochondria DNA Mutations in Diseases. Adv Exp Med Biol. 2017;1038:219-230. doi: 10.1007/978-981-10-6674-0_15.
2016
Song D, Cretoiu D, Zheng M, Qian M, Zhang M, Cretoiu SM, Chen L, Fang H, Popescu LM, Wang X. Comparison of Chromosome 4 gene expression profile between lung telocytes and other local cell types. J Cell Mol Med. 2016 Jan;20(1):71-80. (IF=4.938)
Zheng Y, Wang X. Roles of Telocytes in the Development of Angiogenesis. Adv Exp Med Biol. 2016;913:253-261.
Wang J, Jin M, Ma WH, Zhu Z, Wang X. The History of Telocyte Discovery and Understanding. Adv Exp Med Biol. 2016;913:1-21.
Jia Y, Fang X, Zhu X, Bai C, Zhu L, Jin M, Wang X, Hu M, Tang R, Chen Z. IL-13+ Type 2 Innate Lymphoid Cells Correlate with Asthma Control Status and Treatment Response. Am J Respir Cell Mol Biol. 2016 Nov;55(5):675-683.
Wang B, Shi L, Sun X, Wang L, Wang X, Chen C. Production of CCL20 from lung cancer cells induces the cell migration and proliferation through PI3K pathway. J Cell Mol Med. 2016 May;20(5):920-9. (IF=4.938)
Song D, Cretoiu D, Cretoiu SM, Wang XD. Telocytes and lung disease. Histol Histopathol. 2016 Dec;31(12):1303-14 (IF=1.875)
Wei H, Hou J, Pan J, Su X, Li L, Wang XD, Chen Z. A sarcoidosis-like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification Clin Respir J. 2016 Jul;10(4):530-4. (IF=2.147)
Fang T, Hou J, He M, Wang L, Zheng M, Wang XD, Xia J. Actinidia Chinensis Planch root extract (acRoots) inhibits hepatocellular carcinoma progression by inhibiting EP3 expression. Cell Biol Toxicol. 2016 Dec;32(6):499-511. (IF=2.842)
Wang XD. New biomarkers and therapeutics can be discovered during COPD-lung cancer transition. Cell Biol Toxicol. 2016 Oct;32(5):359-61 (IF=2.842)
Wang XD. CBT Profiles of Cabozantinib Approved for Advanced Renal Cell Carcinomas. Cell Biol Toxicol. 2016 Aug;32(4):259-61. (IF=2.842)
Bao L, Diao H, Dong N, Su X, Wang B, Mo Q, Yu H, Wang XD, Chen C. Histone deacetylase inhibitor induces cell apoptosis and cycle arrest in lung cancer cells via mitochondrial injury and p53 up-acetylation. Cell Biol Toxicol. 2016 Dec;32(6):469-482. (IF=2.842)
Bao L, Zhang Y, Wang J, Wang H, Dong N, Su X, Xu M, Wang XD. Variations of chromosome 2 gene expressions among patients with lung cancer or non-cancer. Cell Biol Toxicol. 2016 Oct;32(5):419-35. (IF=2.842)
Shi L, Dong N, Fang XC, Wang XD. Regulatory mechanisms of TGF-β1-induced fibrogenesis of human alveolar epithelial cells. J Cell Mol Med. 2016 Nov;20(11):2183-2193. (IF=4.938)
Gu JY, Wang XD. New Future of Cell Biology and Toxicology: Thinking Deeper. Cell Biol Toxicol, Cell Biol Toxicol. 2016 Feb;32(1):1-3. (IF=2.842)
Shi L, Dong N, Chen C, Wang XD. Potential roles of telocytes in lung diseases. Semin Cell Dev Biol. 2016 Jul;55:31-9. (IF=5.181)
Wang DC, Wang X, Chen C. Effects of anti-human T lymphocyte immune globulins in patients: new or old. J Cell Mol Med. 2016 Sep;20(9):1796-9 (IF=4.938)
Niu F, Wang DC, Lu JP, Wu W, Wang XD. Potentials of single-cell biology in identification and validation of disease biomarkers. J Cell Mol Med. 2016 Sep;20(9):1789-95 (IF=4.938)
Zhou J, Jiang L, Long X, Fu C, Wang XD, Wu X, Liu Z, Zhu F, Shi J, Li S. Bone-marrow-derived mesenchymal stem cells inhibit gastric aspiration lung injury and inflammation in rats. J Cell Mol Med. 2016 Sep;20(9):1706-17. (IF=4.938)
Wang XD. Cancer Moonshot 2020: a new march of clinical and translational medicine. Clin Transl Med. 2016 Mar;5(1):11.
Wang XD. Gene mutation-based and specific therapies in precision medicine. J Cell Mol Med. 2016 Apr;20(4):577-80. (IF=4.938)
Chen C, Shi L, Li Y, Wang XD, Yang S. Disease-specific dynamic biomarkers selected by integrating inflammatory mediators with clinical informatics in ARDS patients with severe pneumonia. Cell Biol Toxicol. 2016 Jun;32(3):169-84. (IF=2.842)
2015
Wang J, Ye L, Jin M, Wang XD. Global analyses of Chromosome 17 and 18 genes of lung telocytes compared with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. Biol Direct. 2015 Mar 11;10:9. (IF=3.016)
王向东 何明燕 陈成水. 精准医学:与临床实践有多远? 国际呼吸杂志2015年4月第35卷第7期 Int J Respir, April2015, Vol.35, No.7
陈智鸿，苏孝琼，王向东. 哮喘临床分型和个体化治疗的转化应用. 转化医学研究。季刊 2011 年 9 月创刊 第 4 卷 第 4 期 2014 年 12 月 出版 95－104
Wang X, Adjei AA.Lung cancer and metastasis: new opportunities and challenges. Cancer Metastasis Rev. 2015 Jun;34(2):169-71. (IF=5.316)
Wu DJ, Wang XD. Application of clinical bioinformatics in lung cancer-specific biomarkers. Cancer Metastasis Rev. 2015 Jun;34(2):209-16. (IF=5.316)
Wang XD, Zhang Y, Nilsson CL, Berven F, Andrén PE, Carlsohn E, et al. Association of Chromosome 19 to Lung Cancer Genotypes and Phenotypes. Cancer Metastasis Rev. 2015 Jun;34(2):217-26. (IF=5.316)
Zhang Y, Wang HY, Wang J, Bao L, Wang LY, Huo JY, Wang XD. Global analysis of chromosome 1 genes among patients with lung adenocarcinoma, squamous carcinoma, large cell carcinoma, small cell carcinoma, or non-cancer. Cancer Metastasis Rev. 2015 Jun;34(2):249-64. (IF=5.316)
Zhang D, Chen ZH, Wang XD Regulatory T cells and potential inmmunotherapeutic targets in lung cancer. Cancer Metastasis Rev. 2015 Jun;34(2):277-90. (IF=5.316)
Ye L, Jing ML, Wang XD Allosteric therapies for lung cancer.Cancer Metastasis Rev. 2015 Jun;34(2):303-12. (IF=5.316)
Shi L, Wang LY, Jia JY, Zhu BJ, Ming ZH, Zhang MM, Song DL, Cheng YF, Wang XD. Targeting roles of inflammatory microenvironment in lung cancer and metastasis. Cancer Metastasis Rev. 2015 Jun;34(2):319-31. (IF=5.316)
Wang J, Zhang Y, Wang HY, Dong N, Bao LN, Sun XQ, Xu ML, Wang XD. Global analyses of subtype- or stage-specific genes on chromosome 7 in patients with lung cancer. Cancer Metastasis Rev. 2015 Jun;34(2):333-45(IF=5.316)
Ling Y, Wang J, Wang LY, Hou JY, Qian PY, Wang XD Roles of CEACAM1 in cell communication and signaling of lung cancer and other diseases. Cancer Metastasis Rev. 2015 Jun;34(2):347-57. (IF=5.316)
Chen CS, He MY, Zhu YC, Shi L, Wang XD. Five critical elements to ensure the precision medicine. Cancer Metastasis Rev. 2015 Jun;34(2):313-8(IF=5.316)
Wei HL, Hou J, Pan J, Su XQ, Li LQ, Wang XD, Chen ZH. A sarcoidosis-like granuloma reaction in the lymph nodes of a patient with lung squamous cancer: from stasis to the invasive phase with FGFR1 gene amplification. Clin Respir J. 2016 Jul;10(4):530-4. (IF=2.147)
Wang JW, Gong XH, Ding N, Chen XF, Sun L, Tang Z, Yu DH, Yuan ZP, Wang XD, Yu JM. The influence of comorbid chronic diseases and physical activity on quality of life in lung cancer survivors. Support Care Cancer. 2015 May;23(5):1383-9. (IF=2.535)
Yang DW, Zhou J, Zeng T, Yang ZY, Wang X, Hu J, Song YL, Chen LN, Peer D, Wang XD, Bai CX. Serum chemokine network correlates with chemotherapy in non-small cell lung cancer. Cancer Lett. 2015 Aug 28;365(1):57-67(IF=5.992)
Yu XT, Zeng T, Wang XD, Li GJ, Chen LN. Unravelling personalized dysfunctional gene network of complex diseases based on differential network model. J Transl Med. 2015 Jun 13;13:189. (IF=3.694)
Zhu Y, Wang W, Wang XD. Roles of transcriptional factor 7 in production of inflammatory factors for lung diseases. J Transl Med. 2015 Aug 20;13:273. (IF=3.694)
He SH, Mao XQ, Sun HZ, Shirakawa T, Zhang HY, Wang XD. Potential therapeutic targets in the process of nucleic acid recognition: opportunities and challenges. Trends Pharmacol Sci. 2015 Jan;36(1):51-64. (IF=11.84)
Zhu Y, Zheng M, Song D, Ye L, Wang X. Global comparison of chromosome X genes of pulmonary telocytes with mesenchymal stem cells, fibroblasts, alveolar type II cells, airway epithelial cells, and lymphocytes. J Transl Med. 2015 Sep 28;13:318. (IF=3.694)
论著
Serial Book: Translational Bioinformatics, Editor: Xiangdong Wang
Volume 1 (2012): Applied Computational Genomics. Editors: Yin Yao Shugart. ISBN: 978-94-007-5557-4 (Print) 978-94-007-5558-1 (Online)
Volume 2 (2012): Pediatric Biomedical Informatics: Computer Applications in Pediatric Research. Editors: John J. Hutton. ISBN: 978-94-007-5148-4 (Print) 978-94-007-5149-1 (Online)
Volume 3 (2013): Bioinformatics of Human Proteomics. Editors: Xiangdong Wang. ISBN: 978-94-007-5810-0 (Print) 978-94-007-5811-7 (Online)
Volume 4 (2013): Bioinformatics for Diagnosis, Prognosis and Treatment of Complex Diseases. Editors: Bairong Shen. ISBN: 978-94-007-7974-7 (Print) 978-94-007-7975-4 (Online)
Volume 5 (2014): Genomics and Proteomics for Clinical Discovery and Development. Editors: György Marko-Varga. ISBN: 978-94-017-9201-1 (Print) 978-94-017-9202-8 (Online)
Volume 6 (2015): Computational and Statistical Epigenomics. Editor: Andrew E. Teschendorff. ISBN: 978-94-017-9926-3 (Print) 978-94-017-9927-0 (Online)
Volume 7 (2015): Single Cell Sequencing and Systems Immunology. Editor: Xiangdong Wang. ISBN: 978-94-017-9752-8 (Print) 978-94-017-9753-5 (Online)
Volume 8 (2015): Allergy Bioinformatics. Editors: Tao, Ailin, Raz, Eyal. eBook ISBN: 978-94-017-7444-4; DOI: 10.1007/978-94-017-7444-4; Hardcover ISBN: 978-94-017-7442-0
Volume 9 (2016): Transcriptomics and Gene Regulation. Editors: Wu, Jiaqian (Ed.) eBook ISBN: 978-94-017-7450-5, DOI: 10.1007/978-94-017-7450-5, Hardcover ISBN: 978-94-017-7448-2; Series ISSN: 2213-2775
Volume 10 (2016): Application of Clinical Bioinformatics. Editors: Wang, X., Baumgartner, C., Shields, D., Deng, H.-W., Beckmann, J.S. eBook ISBN: 978-94-017-7543-4, DOI: 10.1007/978-94-017-7543-4, Hardcover ISBN: 978-94-017-7541-0, Series ISSN: 2213-2775
Volume 14 (2018): Lipidomics in Health & Disease: Methods & Application. Editors: Wang X, Wu D, Shen H. DOI: https://doi.org/10.1007/978-981-13-0620-4. In: Translational Bioinformatics (Book Series) edited by Wang X, Published by Springer, Singapore.
Serial Book: Advances in Experimental Medicine and Biology
Volume 913: Telocytes: Connecting Cells, Edited Wang X, Cretoiu D. Series Title: Advances in Experimental Medicine and Biology, 2016, eBook ISBN978-981-10-1061-3, Hardcover ISBN: 978-981-10-1060-6, Softcover ISBN: 978-981-10-9318-0, Series ISSN: 0065-2598, DOI:10.1007/978-981-10-1061-3, Published by Springer Singapore.
白春学，王向东，韩江娜. 主编《国际医学期刊论文撰写指南》. 人民军医出版社，北京，2011.
荣誉和奖励 （Honors and Awards）
2012 2012年上海市科技进步奖二等：急性肺损伤发病机制、诊治新技术研究和临床应用 白春学，宋元林，蒋进军，王向东，宋振举，杨冬，王桂芳 复旦大学附属中山医院，20120803.
2012 获浙江省“高端外国专家项目”（文教类）
2011 获浙江省“千人计划”（创新人才）
2011 获温州市 “580海外精英引进计划”
2010 获温州市政府“雁荡山友谊奖”
2006 Proteomic approaches to understanding of organ dysfunction 获蛋白谱研究杂志2006年最突出文
2004 Proteomics and leukocytes: An approach to understanding potential molecular mechanisms of inflammatory responses获蛋白谱研究杂志2004年最佳十篇文章（第四）
1999 获英国剑桥21世纪优秀科学家 （Outstanding Scientists of the 20th Century， Cambridge， UK）
1999 获Marquis Who’s Who in America， ABI， USA， Who’s who in Medicine and Healthcare， ABI， USA；Who’s whoe in Science and Engineering ， ABI， USA
1995 Hepatocyte transplantation: A potential treatment for acute liver failure获现代胃肠杂志最佳综述
1998 肠缺血再灌流至肠屏障功能紊乱获第18界国际重症护理与急救医学大会优秀论文奖（18th International Symposium on Intensive Care and Emergency Medicine）.
1994 肝细胞与胰岛细胞联合移植治疗急性肝衰竭病人--获中国教育部优秀青年教师基金
1994 急性胰腺炎引起的多器官功能紊乱综合症--获瑞典皇家生理学会青年科技奖 KUNGL FYGIOGRAFISKA SÄLLSKAPET （Rayal Physiological Association）， Sweden
1993 肝损伤中的肠源性感染--获瑞典隆德大学优秀博士奖
1987 优化经皮肝胆引流方法--获黑龙江省科技进步奖
1987 梗阻性黄疸术前准备和术后处理时病人肝胆超微结构的研究--获中华电镜学会青年科技奖
1987 梗阻性黄疸术前准备和术后处理时病人肝胆超微结构的研究--获黑龙江省电镜学会青年科技奖
1985 医院质量控制管理--获中华医学会管理奖
专利申请和现状 (2008-2010)
专利名称（类别） 专 利 号 专利
类别 国别 申请·公告·获准
一种用于预测慢性阻塞性肺病的试剂盒 200910045595 发明 中国 公告
可用于诊断慢性舒张性心力衰竭的试剂盒 200910201045.4 发明 中国 公告
远程呼吸监护医疗系统 200920078022.4 实用新型 中国 获准
一种呼吸机换能器 200920078023.9 实用新型 中国 获准
用于诊断肾移植后急性排斥反应的试剂盒 201020266073.7 发明 中国 公告
一种用于辅助模块化心肺功能监护的系统 201020530839.9 实用新型 中国 申请
一种用于肺功能指标辅助诊断的系统 201020530812.4 实用新型 中国 申请
用于诊断非小细胞肺癌的试剂盒 201210262372.2 发明 中国 申请
用于评估肺腺癌化疗效果的试剂盒 201210262363.3 发明 中国 申请
用于预测肺腺癌生存时间的试剂盒 201210261301.6 发明 中国 申请
用于预测慢性阻塞性肺病的酶联免疫检测板及试剂盒 CN202614768U 实用新型 中国 公告
用于诊断慢性阻塞性肺病急性加重期的试剂盒 1377860 发明 中国 公告
