1．个人信息

　　男，医学博士，主任医师、教授，现任河南省立眼科医院常务副院长、河南省眼科研究所常务副所长、河南省人民医院眼科主任，中华医学会眼科分会委员，眼科专家会员、中华医学会眼科分会眼底病学组委员、中国医师协会眼科常委、眼外伤学组委员；国家防盲技术指导专家、河南省防盲技术指导组组长；河南省医学会眼科分会侯任主委、河南省医师协会眼科分会会长；中文核心期刊《中华眼底病杂志》编委等。邮箱：szmeyes@126.com。

2．受教育经历

　　1985.9-1989.6商洛地区卫校；1989.09-1991.07延安医学院，临床医学专业；1995.09-1998.07西安医科大学，获硕士学位；1998.09-2001.07年于第四军医大学，获医学博士学位。

3．工作经历

　　2001.07-2016.11就职于温州医科大学附属眼视光医学；2016.12至今就职于河南省人民医院眼科。

4．研究兴趣

　　主要研究复杂性视网膜脱离、复杂眼外伤、黄斑疾病、糖尿病眼底病变、复杂白内障及白内障术后并发症等眼底疾病的诊断和手术治疗，尤其擅长超声乳化联合微创玻切治疗眼底疾病。

5．承担项目情况

　　现承担国家自然科学基金项目等项目近10项，科研经费300余万元。

6．代表性论著

　　发表科研论文一百余篇。其中近5年发表37篇，获国家发明专利2项。

　　代表性论文：

[1] Yufei Wang1,†, Bang Wang1,†, Haihua Xie1, Qianwen Ren1, Xiexie Liu1, Fanfan Li2, Xiujuan Lv1, Xiubin He1, Congsheng Cheng2, Ruzhi Deng1, Jin Li1, Junzhao Zhao2, Zongming Song1,3,*(通讯), Feng Gu1,*(通讯).Efficient human genome editing using SaCas9 ribonucleoprotein complexes. Biotechnology Journal, 2019 Accepted.

[2] Zheng B, Chen Y, Chen L, Chen H, Zheng J, Chen F, Song Z, Fu L, Hu X, Pan J, Lian H, Shen L, Li Q. Comparative Study on the Efficacy and Safety of Tumor Resection in Vitrectomy for Retinal Vasoproliferative Tumors. J Ophthalmol. 2019 Jan 2;2019:7464123. doi: 10.1155/2019/7464123. eCollection 2019.

[3] Ju, X, Yang, X, Yan, T, Chen, H, Song Z，Zhang Z, Wu W，Wang, Y. EGFR inhibitor, AG1478, inhibits inflammatory infiltration and angiogenesis in mice with diabetic retinopathy. Clinical and Experimental Pharmacology and Physiology.2019, 46(1):75-85. (4 区, IF: 2.092)

[4] Lin L, He X, Zhao T, Gu L, Liu Y, Liu X, Liu H, Yang F, Tu M, Tang L, Ge X, Liu C, Zhao J, Song Z, Qu J, Gu F.Engineering the Direct Repeat Sequence of crRNA for Optimization of FnCpf1-Mediated Genome Editing in Human Cells. Mol Ther. 2018 Nov 7;26(11):2650-2657. doi: 10.1016/j.ymthe.2018.08.021. Epub 2018 Sep 1. IF 6.5858, JCR 1

[5] Wang L, Chen HC, Yang X, Tao JJ, Liang G, Wu JZ, Wu WC, Wang Y, Song ZM(通讯), Zhang XM(通讯). The novel chalcone analog L2H17 protects retinal ganglion cells from oxidative stress-induced apoptosis. Neural Regen Res 13(9):1665-1672. doi:10.4103/1673-5374.237140. IF 2.234, JCR 4

[6] Xuting Hu，Tianyu Chen, Zhongqiang Zhou, Zongduan Zhang, Zongming Song(通讯). Predictive clinical features and efficacy of preoperativeanti-VEGF treatment on visual acuity in patients with proliferative diabetic retinopathy. Int J Clin Exp Med 2018;11(7):7376-7383 IF 0.833，JCR 4

[7] Yang F, Ge X, He X, Liu X, Zhou C, Sun H, Zhang J, Zhao J, Song Z, Qu J, Liu C, Gu F. Functional non-homologous end joining patterns triggered by CRISPR/Cas9 in human cells. J Genet Genomics. 2018 May 8. pii: S1673-8527(18)30078-X. doi: 10.1016/j.jgg.2018.02.009. IF4.066， JCR 2

[8] Sun H, Li F, Liu J, Yang F, Zeng Z, Lv X, Tu M, Liu Y, Ge X, Liu C, Zhao J, Zhang Z, Qu J, Song Z, Gu F. A Single Multiplex crRNA Array for FnCpf1-Mediated Human Genome Editing. Mol Ther. 2018 Jun 15. pii: S1525-0016(18)30249-1. doi: 10.1016/j.ymthe.2018.05.021. IF 7.008， JCR 1

[9] Chen T, Su B, Chen Z, Tong J, Bedell H, Song Z(通讯), Zhang B(通讯).The associations among metamorphopsia, orientation discrimination threshold, and retinal layer thickness in patients with idiopathic epiretinal membrane. Curr Eye Res. 2018 May 26. doi: 10.1080/02713683.2018.1481515. [Epub ahead of print]. IF2.238, JCR 3

[10] Wang Y, Li H, Zang S, Li F, Chen Y, Zhang X, Song Z, Peng Q, Gu F. Photoreceptor Cell-Derived CAPN5 Regulates Retinal Pigment Epithelium Cell Proliferation Through Direct Regulation of SLIT2 Cleavage. Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):1810-1821. doi: 10.1167/iovs.17-22689. IF3.303， JCR 2

[11] Chen H, Song Z(并列第一), Ying S, Yang X, Wu W, Tan Q, Ju X, Wu W, Zhang X, Qu J, Wang Y. Myeloid differentiation protein 2 induced retinal ischemia reperfusion injury via upregulation of ROS through a TLR4-NOX4 pathway.Toxicol Lett. 2018 Jan 5;282:109-120. doi: 10.1016/j.toxlet.2017.10.018. Epub 2017 Oct 27.IF 3.858, JCR 2

[12] Ding Chen, Tao Xu，Mengjun Tu,Jinlin Xu, Chenchen Zhou, Lulu Cheng, Ruqing Yang, Tanchu Yang, Weiwei Zheng, Xiubin He, Ruzhi Deng, Xianglian Ge, Jin Li,Zongming Song, Junzhao Zhao, and Feng Gu. Recapitulating X-Linked Juvenile Retinoschisis in Mouse Model by Knock-In Patient-Specific Novel Mutation. Front Mol Neurosci. 2017; 10: 453.Published online 2018 Jan 12. doi: 10.3389/fnmol.2017.00453. IF 5.076，JCR2

[13] Lei Lei, Xianglian Li, Taotao Xiong, Jing Yu, Xinxin Yu, Zongming Song(通讯), Xingyi Li(通讯). Covalently Cross-Linked Chitosan Hydrogel Sheet for Topical Ophthalmic Delivery of Levofloxacin. J. Biomed. Nanotechnol. 2018, (14)371–378.IF 4.521, JCR 2

[14] Xie H, Tang L, He X, Liu X, Zhou C, Liu J, Ge X, Li J, Liu C, Zhao J, Qu J, Song Z(通讯), Gu F(通讯). SaCas9 Requires 5'-NNGRRT-3' PAM for Sufficient Cleavage and Possesses Higher Cleavage Activity than SpCas9 or FnCpf1 in Human Cells. Biotechnol J. 2017 Dec 16. doi: 10.1002/biot.201700561. IF 3.649,JCR2

[15] Mengjun Tu, Li Lin, Yilu Cheng, Xiubin He, Huihui Sun, Haihua Xie, Junhao Fu, Changbao Liu, JinLi, Ding Chen, Haitao Xi, Dongyu Xue, Qi Liu, Junzhao Zhao, Caixia Gao, Zongming Song, Jia Qu , Feng Gu. A ‘new lease of life’: FnCpf1 possesses DNA cleavage activity for genome editing in human cells. Nucleic Acids Research, 2017， 1，doi: 10.1093/nar/gkx783. IF 10.162. JCR 1

[16] Yan Wang, Xiao Zhang, Zongming Song, Feng Gu. An anti-CAPN5 intracellular antibody acts as an inhibitor of CAPN5-mediated neuronal degeneration. Oncotarget. 2017 Nov 1;8(59):100312-100325. doi: 10.18632/oncotarget.22221. eCollection 2017 Nov 21. IF 5.168, JCR 2

[17] Huiqiong Chen, Tangbing Liu, Zhenhai Zeng, Yufei Wang, Yuanyuan Lin, Lulu Cheng, Qintuo Pan, Feng Gu(通讯), Zongming Song(通讯), Zongduan Zhang. Clinical characteristics of a KIF21A mutation in a Chinese family with congenital fibrosis of the extraocular muscles type1. Medicine (Baltimore)2017Sep;96(38): e8068.IF 1.803,JCR3

[18] Ren L, Tao J, Chen H, Bian Y, Yang X, Chen G, Zhang X, Liang G, Wu W, Song Z(通讯), Wang Y(通讯). Myeloid differentiation protein 2-dependent mechanisms in retinal ischemia-reperfusion injury.Toxicol Appl Pharmacol. 2017 Feb 15;317:1-11. doi: 10.1016/j.taap.2017.01.001. Epub 2017 Jan 4. IF 3.791，JCR 2

[19] Fayu Yang, Changbao Liu, Ding Chen, Mengjun Tu, Haihua Xie, Huihui Sun, Xianglian Ge, Lianchao Tang, Jin Li, Jiayong Zheng, Zongming Song, Jia Qu, Feng Gu. CRISPR/Cas9-loxP-Mediated Gene Editing as a Novel Site-Specific Genetic Manipulation Tool. Mol Ther Nucleic Acids. 2017 Jun 16; 7: 378–386. 2017 Apr 25. doi: 10.1016/j.omtn. 2017.04.018. IF 6.392，JCR 2.

[20] Lin Z, Ke ZS, Zheng Q, Zhao ZQ, Song ZM. Passive Removal of Silicone Oil with Temporal Head Position through Two 23-Gauge Cannulas. J Ophthalmol. 2016;2016:4182693. doi: 10.1155/2016/4182693. Epub 2016 Jun 22. IF 1.712, JCR 4

[21] Song ZM, Hu XT, Wang L, Hu ZX, Zhao PQ, Chen D. A modified approach to actively remove high viscosity silicone oil through 23-gauge cannula. A modified approach to actively remove high viscosity silicone oil through 23-gauge cannula. Int J Ophthalmol. 2016 Sep 18;9(9):1294-8. doi: 10.18240/ijo.2016.09.10. eCollection 2016.IF 1.077, JCR 4

[22] Wu W, He Z, Zhang Z, Yu X, Song Z（通讯）, Li X（通讯）. Intravitreal injection of rapamycin-loaded polymeric micelles for inhibition of ocular inflammation in rat model. Int J Pharm. 2016 Sep 5;513(1-2):238-246. doi: 10.1016/j.ijpharm.2016.09.013. IF3.650, JCR 2

[23] Song Z，Li M，Liu J，Hu X，Hu Z，Chen D. Viscoat Assisted Inverted Internal Limiting Membrane Flap Technique for Large Macular Holes Associated with High Myopia. J Ophthalmol. 2016;2016:8283062. doi: 10.1155/2016/8283062. Epub 2016 Mar 7. IF1.935. JCR 4

[24] Bi XZ，Pan WH，Yu XP，Song ZM，Ren ZJ，Sun M，Li CH，Nan KH. Application of 5-Fluorouracil-Polycaprolactone Sustained-Release Film in Ahmed Glaucoma Valve Implantation Inhibits Postoperative Bleb Scarring in Rabbit Eyes. PLoS One. 2015 Nov 18;10(11):e0141467. doi: 10.1371/journal.pone.0141467. eCollection 2015. IF=3.5. JCR 3

[25] Bian Y，Ren L，Wang L，Xu S，Tao J，Zhang X，Huang Y，Qian Y，Zhang X，Song Z，Wu W，Wang Y，Liang G. A novel imidazopyridine derivative，X22，prevents the retinal ischemia-reperfusion injury via inhibition of MAPKs. Exp Eye Res. 2015 Jun;135:26-36. doi: 10.1016/j.exer.2015.04.010. Epub 2015 Apr 20. IF=2.70, JCR 3

[26] Xie B，Jin L，Luo Z，Yu J，Shi S，Zhang Z，Shen M，Chen H，Li X，Song Z（通讯）.An injectable thermosensitive polymeric hydrogel for sustained release of Avastin® to treat posterior segment disease. Int J Pharm. 2015 Jul 25;490(1-2):375-83. doi: 10.1016/j.ijpharm.2015.05.071. Epub 2015 May 28. (IF=3.650) JCR 2

[27] Zhou F，Zhang YK，Song ZM（通讯）. Potential role of Cyr61 induced degeneration of human Müller cells in diabetic retinopathy. PLoS One. 2014 Oct 16;9(10):e109418. doi: 10.1371/journal.pone.0109418. eCollection 2014. (IF=3.534),JCR 3

[28] Jiang H，Du J，He T，Qu J，Song Z(通讯)，Wu S（通讯）. Increased D-serine in the aqueous and vitreous humor in patients with proliferative diabetic retinopathy. Clin Experiment Ophthalmol. 2014 Mar 19. doi: 10.1111/ceo.12329. [Epub ahead of print] IF 2.347,JCR 3

[29] Song ZM. PI3K-mediated glioprotective effect of EGF under oxidative stress conditions. Int J Ophthalmol. 2014 Jun 18;7(3):413-20. IF 0.705,JCR 4

[1] 吴越，胡志翔，胡旭颋，厉芬芬 ，雷祥，宋宗明（通讯）.板层黄斑裂孔相关视网膜前增生膜填塞联合自体血覆盖治疗退行型板层黄斑裂孔的疗效观察.中华眼底病杂志2017（6）616-20

[2] 潘伟华，毕秀增，余新平，宋宗明. 缝线植入Schlemm管开口部成形联合小梁切除术治疗原发性开角型青光眼三年疗效观察. 中华眼科杂志, 2016,52(6) : 416-421.

[3] 曹文俊，陈蔚，陈东科，康玉国，李向阳，李雅君，梁庆丰，梁远波，刘莉英，鹿秀梅，马文江，瞿佳，宋宗明，孙声桃，许芬芬，俞阿勇，赵振全，郑美琴. 感染性眼病细菌学检查操作共识. 中华实验眼科杂志，2016,1（18）1-4.

[4] 陈春丽1, 宋宗明, 贾新国, 周仲楼, 汪朝阳. 促红细胞生成素抑制氧化损伤诱导的人眼Müller细胞凋亡.山东大学耳鼻喉眼学报 2015, 29 (3): 65-71 DOI: 10.6040/j.issn.1673-3770.0.2014.293

[5] 黄建国, 刘俊杰, 宋宗明.视盘小凹合并黄斑裂孔一例. 中华眼底病杂志, 2015,31(6) 603-604.10.3760/cma.j.issn. 1005 - 1015. 2015.06.026

[6] 张娅萍, 毛广运, 王毓琴, 宋宗明, 薛安全. 后巩膜加固手术治疗病理性近视黄斑劈裂的疗效观察疗. 中华眼底病杂志 2015,324-328

[7] 周芬，任增金，王瑞华，柯治生，胡志翔，宋宗明(通讯). 2 3 G和2 0 G玻璃体切除术治疗高度近视黄斑裂孔性视网膜脱离比较.实用眼科杂志，2014,32（1）32-6

[8] 周芬，柯治生，曲鹏，宋宗明(通讯). 特发性黄斑裂孔手术后视力和光感受器内外节连接的变化. 实用眼科杂志，2014,30（3）257-60

　　专利：

　　1、一种贝伐单抗滴眼液及其制备方法. 发明专利（ZL 2013 1 0337426.1）授权时间2016.1.6.

　　2、一种白介素18眼内控释剂的制作方法. 发明专利（ZL 2013 1 05276973），授权时间2015.11.18

　　主持课题

[1] PEG-PLL-IPEI抗体聚合物靶向VEGFR2基因编辑治疗视网膜新生血管的新药研究. 河南省重点研发与推广专项（科技攻关项目）.2019

[2] 超广角高清多波长真彩色眼底相机. 河南省科技基础条件专项资金，2019

[3] 人工智能辅助眼底成像系统在糖尿病视网膜病变等致盲性眼病诊疗的应用示范. 河南省医学科技攻关省部共建项目SBGJ2018080，2018.07.01-2021.07.01

[4] 新生血管性AMD患者接受重组抗VEGF人源化单克隆抗体注射液（代号TK001）-多次给药的I期临床研究. 江苏泰康生物医药有限公司（横向）Tmab-TK001-AMD-02，2018.1-2018.12

[5] 河南省省直医疗机构医疗服务能力提升工程建设项目.河南省卫生和计划生育委员会文件[2017]66，2017.1-2019.12

[6] 河南省人民医院23456人才工程，2017.1-2020.12

[7] 靶向髓样分化蛋白2的小分子抑制剂对视网膜缺血再灌注损伤的疗效研究. 国家自然科学基金面上项目81473295，2015.1-2018.12

[8] IL-18通过p38/JNK间crosstalk介导VEGF表达在糖尿病视网膜病变中的作用机制研究. 国家自然科学基金面上项目 81670882，2017.1-2020.12

[9] 眼内有色灌注液的研究和开发. 浙江省科技计划，2014C33260，2014.1.1-2016.12

[10] IL-18在糖尿病视网膜病变发生中的作用及关键机制研究，浙江省自然科学基金（LY13H120004），2013.1-2015.12